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العنوان
Colloidal Carriers For Transmucosal Drug Delivery /
المؤلف
Mohamed, Heba Mohamed Abd El Azim.
هيئة الاعداد
باحث / هبة محمد عبد العظيم محمد
مشرف / نوال محمد خلف الله
مشرف / نهى عادل نافع
مشرف / علياء عادل رمضان
الموضوع
Pharmaceutics.
تاريخ النشر
2014.
عدد الصفحات
105 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة
تاريخ الإجازة
1/5/2014
مكان الإجازة
جامعة الاسكندريه - كلية الصيدلة - الصيدلانيات
الفهرس
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Abstract

The present thesis focused on drug delivery via the buccal route, as a potential
route for systemic delivery of water soluble vitamins. Pyridoxine hydrochloride (VB6)
was selected in this thesis as a model water soluble vitamin. A considerable volume of
research has been devoted, in the past decades, to the buccal route for systemic delivery
of various drugs and dietary supplements including vitamins.
The buccal route has attracted considerable attention as an alternative route for
systemic drug delivery to overcome the limitations of conventional drug delivery routes.
Invasive parenteral administration and poor bioavailability, drug degradation or intensive
metabolism through oral route all can be avoided by buccal drug administration.
Additionally, ease of drug administration, excellent accessibility, higher patient
compliance, versatility in formulation design to accommodate different purposes,
suitability for rapid onset of action in emergency due to rich vascularization of buccal
mucosa, possibility for sustained drug release and permeability exceeding skin by 4000
times can be achieved through buccal drug delivery.
The buccal mucosa is 500 – 600 μm and consists of stratified multilayered
squamous epithelium separated from the underlying connective tissue by continuous
undulating basement membrane. The upper one-third to one-quarter of the buccal
epithelium generally forms the rate limiting barrier of the buccal mucosa. Drugs passively
traverse the buccal mucosa by paracellular and/or transcellular route depending on their
physicochemical properties.
However, the rapid elimination of drugs due to the flushing action of saliva or the
ingestion of foods stuffs and lack of dosage form retention at the site of absorption may
lead to the requirement for frequent dosing and interruption of drug delivery. Thus,
mucoadhesive dosage forms have been developed to localize the drug at absorption site
and extend the contact time with buccal tissue. Various mucoadhesive buccal dosage
forms have been introduced including adhesive tablets, gels, ointments, patches and more
recently films.
Liposomes are self-assembling sphere-shaped vesicles consisting of one or more
phospholipid bilayers surrounding aqueous units with sizes ranging from a few
nanometers to several micrometers. Liposomes have versatile applications in
pharmaceutical drug delivery, biotechnology, cosmetology, food and farming industries.
Liposomes are non toxic, flexible, biocompatible, completely biodegradable, and non
immunogenic drug carriers. They offer many advantages such as suitability for sustained
release systemic and non-systemic administration, improved solubility of drugs, improved
transfer of hydrophilic and charged molecules, improved penetration into tissues, passive
and active targeting, increased efficacy and therapeutic index of drug, increased drug
stability, reduced side effects and toxicity of the encapsulated agent.