الفهرس 
(Autoimmune HepatitisOnly 14 pages are availabe for public view
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Abstract
Acute presentation (55%) was the most prevalent
mode of presentation followed by chronic form (30%)
and insidious form (15%).
Four patients (20%) preceded with hepatitis A infection,
they showed no significant difference according to the AIH
outcomes.
Antinuclear antibodies (ANA) were positive in (30%) of
patients. Smooth muscle antibodies (SMA) were positive in
(70%) of patients and Liver-kidney microsomal (LKM)
antibody was negative in (80%) of patients.
Liver biopsy was done for 13 patients. It was found that
fibrosis and inflammatory cells infiltrates were the main
histopathological findings while (30.8%) of patients had
cirrhosis. Most patients with cirrhosis at presentation had
incomplete response to treatment. For these 13 patients HAIscoring
-biopsy had been calculated for 5 patients and it was
ranged from 4 to 10.
The most common allele for HLA-DRB1in the studied
group was HLA-DRB1*13.
It was found that (65%) of patients were treated initially
with prednisone alone. At the end of follow up (85%) of
patients were on prednisone in combination with azathioprine.
Only 3 patients (15%) continued on steroid alone but there was
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no statistical significant difference between AIH outcomes in
the studied patients as regard immunosuppressant therapy.
In the present study there was reduction in the
serum ALT and AST after 4-8 weeks of the use of
immunosuppressant therapy but this reduction didn‟t a
reach significant difference. But there was a significant
difference in the last reported results at the end of follow
up as regards total and direct bilirubin levels as both
shows a significant reduction.
Complete remission seen in 14 patients (70%),
incomplete response to therapy seen in 4 patients (20%)
and 2 patients failed to response to treatment due to noncompliance.
Relapse occurred in 13 patients (65%). three and
four times (15%) were the most prevalent in the
frequency of relapses. There was statistical significant
difference between AIH outcomes in the studied patients
as regard frequency of relapse. All patients with no
relapse showed complete response to therapy while
patients with frequency of relapses four times or more
had incomplete response to therapy and treatment
failure.
In the present study 14 patients achieved complete
remission while the long term prognosis at the end of
follow up showed that morbidity (liver cirrhosis and
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portal hypertension) occurred in 6 patients and 1 patient
had died after failure to response to treatment. There
was a statistical significance differences between AIH
outcomes in the studied cases regards long term
prognosis. 66.6% of patients with morbidity had
incomplete response to therapy while the only patient
who died among the studied cases failed to response to
treatment.
Cushinoid features (40%) were the most prevalent
complication related to therapy. Since these side effects
were mild and tolerable, the treatment was not
discontinued, and all these side effects resolved after
prednisone withdrawal.