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Abstract INTRODUCTION AND AIM OF THE WORK HyperuncernHi means 1ncrea~.ed level of serum unc ac1rj .:~bove 7 rng% Hyperuncerr11a 1s often found m patlents ··l·nn, r••~pertens.10n U•nMJII 1958). in man. unc ac1d Js denved from three maJor sources (Befteflict et 11L, 1 952) 1 :< A~. an end product of punne ~-ynU!i?SJc,; from relat.ivel•d ~1mple precursors. wlthout pnor incorporation 1nto tissue .2) Ac. a break down product of t1s:ue nucle1c ac1d and preformed coenzymes. 3) As a result of catabol1sm of dietary punne-contalmng :CJmoc••.md”. c_.uch a·:. ll’·ier. kldne~,J. tw.:nn goo~:e and salmon The ”.olubJIJt•~ or unc .:~cJrj a:; rnono:;orjJurr: ur,:~te 111 plas:r·na .::ppr-o>-1r”,-l,jte·=· 7 rnq/1(10 rn1. th1-=: conc:er,t_~--:J.,._l_on r·1a·:=: cori”::T.Jtut8;J tr1e up~·et- 11r-n1t or norrn:j; •n ·::.everal l.:,t-·~e :·o~~ulatlon :::.t_ucJ:e-: rnq; 1 ’:”:r rnl t’1a’.’8 u·,e n·:-~- oi preclpll.<:d.wrr r::f unc ac10 1n tJs.::.:Je::. e·:.pecJall~,J tne kliJne•~ ’”~S .’i tar·get of rnono ::.c”jJurn ur·.”Jte pr·ec1r;Jto’it10n t··Jan•d rec”:;rt·:. r1ave t•een putrll:::t’,erj on U-.e t·rlgh Jrn:]!Jence oi h•~peru11cerma 1n treaterj and untreaterj patientE: ,:~fiected t·•~ ar-tenal t·:•~perten~Ern (KinseiJ et 111., 1961, lblcovitz •114 Sellen 1963, B..-eeten..-id4je 1966, Messe..-li et al., 1980 |