الفهرس 
Gastric carcinoma
Risk factors of gastric carcinomaOnly 14 pages are availabe for public view
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Abstract
Worldwide, gastric cancer (GC) is the fourth most commonly diagnosed cancer and the second cause of cancer-related deaths, representing
2.2% of total cancer mortality (Xiao et al., 2012). The Egyptian National Cancer Institute (ENCI) reported that the mean incidence of GC represents
1.8% of cancer cases in both sexes in a period from 2002 to 2010 (Alieldin,
2014). Many different systems have been proposed for the histological classification of gastric carcinoma, but the most commonly used are those of
WHO and Lauren. According to Lauren’s classification (Lauren, 1965), gastric carcinoma is classified into; intestinal, diffuse and mixed, while according to WHO classification (Bosman, 2010 ), GC is classified into four major histologic patterns: tubular,papillary, mucinous and poorly cohesive (including signet ring cell carcinoma), plus uncommon histologic variants. GC is classified according to mucin expression (MUC1 and MUC2)
into four mucin phenotypes; Gastric (MUC1+/ MUC2 -), intestinal (MUC1-/ MUC2+), gastrointestinal (MUC1+/ MUC2+) and unclassified (MUC1-/
MUC2-) mucin phenotypes (krstic and Katic, 2008).