الفهرس 
The Immune SystemOnly 14 pages are availabe for public view
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Abstract
Neutrophils are the most important circulating phagocytic cells and therefore, any alteration of their function may increase the susceptibility to infection, especially during the neonatal period when the defense against infection is dependent mainly on the innate immunity.
This cross-sectional study was carried out on 60 subjects (30 infants of diabetic mothers, 15 normal infants, and 15 normal adults). The gestational age ranged from 38 to 40 weeks.
In view of these data, this study aimed to assessment of neutrophils number, neutrophils killing and chemotaxis in patients of infants of diabetic mother.
Neonates with respiratory distress syndrome, neonates with any congenital anomalies, neonates under phototherapy were excluded. All patients were subjected to detailed medical history, thorough clinical examination, laboratory investigations including CBC, DHR, flow cytometric immunophenotyping of CD11b and CD62L.
The results showed that the level of CD11b, CD62L, (L-selectin) and DHR is higher in adults than in infants especially infants of diabetic mothers.
In the present study, we found that the number circulating neutrophils is elevated after birth, with a peak at 12hrs that returns to normal by 22 hours.
The present study showed that the maternal gestational diabetes lead to impairment of cord blood neutrophils motility and phagocytic bactericidal capacity.
In our study, we studied the effect of sex, mode of delivery on neutrophils functions. And there was statistically significant of mode of delivery in DHR level in JDMS. Mean in normal delivery was 75-36 ± 8.79 while in cesarean mean was 66.68 ± 9.94.
In IDMS, there was a significant positive correlation between DHR and CD11b (P value 0.033).
In normal infants, there was a significant negative correlation between DHR & and neutrophils (p value = 0.048).
In normal adults, there was a significant negative correlation between CD11b and WBCs (P value = 0.003) and a significant negative correlation between CD11 and neutrophils (P value < 0.001).
Neonatal neutrophils may have a number of qualitative impairments that adversely affect their capacity to fight infection.
In addition to the quantitative defects, numerous qualitative impairment such as defects in endothelial adherence, transendothelial migration, chemotaxis, phagocytosis, and intercellular killing adversely affect the neonatal neutrophil’s capacity to fight infection.
Gestational diabetes independent of insulin therapy is a risk factor for the impairment of the neutrophil motility and post phagocytic bactericidal capacity in term neonates and reduced cell mediated immunity.