الفهرس 
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Abstract
Summary And Conclusion
Cerebral palsy (CP) is a common neurologic condition that originates in early childhood but affects individuals throughout their life span. Children with CP are known to grow poorly compared with their peers, but it is unclear whether this poor growth is “normal” for the population or a marker of some secondary condition that requires further evaluation and treatment. Richard et al., 2006
Thus, a better understanding of the causes and mechanisms of growth impairment in CP is essential as it could lead to its prevention or treatment in some of those children (Shim et al., 2004). Given the complexity of GH neuroregulation (Nia and Salehi, 2008) it seems logical to postulate that severe brain damage may affect a number of neurotransmitter pathways involved in GH control, thus affecting the normal secretion of the hormone (Reimunde et al., 2010). Moreover, osteopenia is a common finding in children with CP and seems to be associating decreased IGF-1 and IGFBP3 plasma levels, the usual markers of deficient GH secretion (Ali et al., 2007). Other possible causes of decreased growth in CP include psychosocial deprivation and suboptimal nutritional status which are also involved in subnormal GH secretion (Coniglio et al., 1996).
Thus we aimed to detect the levels of GH and IGF-1in children with cerebral palsy with growth retardation in comparison to the control group.
Our study was conducted on 60 children in the pediatric Neurology clinic of Banha University hospitals.
Group I: consist of 40 children (22 males and 18 females) diagnosed as having cerebral palsy.
Group II: 20 children as control (12 males and 8 females) with no history suggestive of neurological disease.
In addition to Careful medical history taking, full medical and neurological examination, including assessing the degree of motor dysfunction of the included subjects according to the Gross Motor Function Measure and Anthropometric measurements evaluation, the following Investigations were done.
(a) Fasting blood samples were collected from all children for assay of GH and IGF-1 by enzyme linked immunosorbant assay (ELIZA).
(b) Fasting blood glucose done for all children
In our study there was significant difference between the studied groups regarding the height, weight, body mass index, these parameters were decreased in the patients, significant decreased levels of GH and IGF-1 in patients, non significant decrease of fasting blood glucose compared to control, positive significant correlation between GH and IGF-1 and between GH and fasting blood glucose level.
In conclusion our results demonstrated significant decrease in levels of GH and IGF-1 in children with cerebral palsy.