الفهرس 
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Abstract
The coccidia consist of a wide variety of single-celled, parasitic animals in the subkingdom Protozoa of the phylum Apicomplexa. Infection by coccidia in sufficient numbers to produce clinical manifestations of disease is called coccidiosis.Avian Coccidiosis is a permanent serious problem in poultry worldwide represent the most common and expensive diseases in the poultry industry and responsible for 6–10% mortality in broiler chicken. It is easily transmissible, and expensive to control.Coccidia infestation produces biochemical changes in infested chicken. The lesions caused by this parasite disturb nutrient absorption, triggering several changes in carbohydrate, lipid, protein, and trace mineral metabolism.Therefore, this study aims to: Investigate the effects of coccidia infestation on several biochemical blood parameters in laying hen, suffered from coccidiosis.To make a procedure for this study, One hundred and twenty laying hen s have been adopted. Laying hens from 3-delta governorates were reared out in air conditioned room at constant environmental and nutritional conditions throughout the periods of the experiment.The first group includes 20 clinically healthy laying hens as control.Every five days for two weeks a fecal samples were taken and investigated in poultry laboratory to ensure the absence of any parasite.The second group includes 100 infested laying hens suffering from coccidiosis as diseased.Chickens received a standard diet without antibiotics or coccidiostats and housed in cages on calcium slat floor.Blood samples were collected in clean and dry sterile sample tubes for Serum separation were separated by centrifugation at 3000 r.p.m for 15 minutes. The clean, clear serum was separated and received in dry sterile sample tubes using sterilized pipettes and then kept in a deep freeze at –20oC until used for subsequent biochemical analysis. All samples were analyzed for the following biochemical parameters: 1- Glucose 2-ALT 3-AST 4-Total Protien 5-Albumin 6-Globulin 7-(A/G) Ratio 8- ALP 9-Total Cholesterol 10- Triglycerides 11-HDL 12- LDL 13-VLDL 14-MDA 15-SOD 16-CAT 17-Iron 18-Calcium 19-In organic phosphorus The obtained results summarized the following: 1- BLOOD GLUCOSE: The coccidia infested group serum glucose concentration value was significant decreased than that the value recorded in the control group.2- ALANINE AMINOTRANSFERASE (ALT): The serum alanine – amino transferase Concentration value was highly significant increased in coccidia infested group than that the value recorded in the control group. 3- ASPARTATE AMINOTRANSFERASE (AST): The coccidia infested group serum Asparatate – amino transferase concentration value was significant increased than that the value recorded in the control group. 4- TOTAL PPROTEIN: The serum Total protien concentration value was significant decreased in coccidia infested group than that the value recorded in the control group. 5- ALBUMIN: The serum Albumin concentration value was significant decreased in coccidia infested group than that the value recorded in the control group.6- GLOBULIN: The serum Globulin concentration value was significant decreased in coccidia infested group than that the value recorded in the control group.7- (A/G) RATIO: The (A/G) ratio value was highly significant decreased in coccidia infested group than that the value recorded in the control group. 8-ALLKALINE PHOSPHATASE (ALK Ph): The Concentration value serum Alkaline phosphatase was highly significant increased in coccidia infested group when compared with the value recorded in the control group.9- TOTAL CHOLESTEROL: Serum cholesterol concentration value was significant decreased in coccidia infested group when compared with the value recorded in the control group. 10- TRIACYLGLYCEROLS:The coccidia infested group serum triglycerides concentration value was significant decreased than that the value recorded in the control group. 11- HDL-CHOLESTEROL: The Concentration value serum HDL-cholesterol was significant decreased in coccidia infested group when compared with the value recorded in the control group.12- LDL - CHOLESTEROL: The serum LDL-cholesterol Concentration value was significant decreased in coccidia infested group than that the value recorded in the control group.13- VLDL - CHOLESTEROL:There is significant decrease in VLDL-cholesterol Concentration value in coccidia infested group than that the value recorded in the control group.14- L-MALANDIALDEHYDE (MDA): The Concentration value serum MDA was significant increased in coccidia infested group when compared with the value recorded in the control group.