الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Hypovitaminosis D has been recently recognized as a worldwide epidemic. Vitamin D plays a pivotal role in calcium homeostasis, skeletal metabolism, immune, cardiovascular, and reproductive systems. Fatty liver is rapidly becoming the most common liver disorder worldwide. The aim of our study is to study vitamin D status in Egyptian patients with non-alcoholic fatty liver disease. Patients and Methods: This study included 75 Egyptian patients with NAFLD detected by abdominal ultrasonography. Serum 25-hydroxyvitamin D level was measured in these patients to study the relation between vitamin D level and the disease compared to control group. Results: Our results illustrated that, 22 patients had vitamin D deficiency (29.3%), 39 patients had vitamin D insufficiency (52%), 11 had vitamin D Sufficiency (14.7%) and 3 had toxic levels of 25(OH) vitamin D (4%). Compared to the control group which showed that 4 persons had deficient vitamin D (5.3%), 22 persons had insufficient vitamin D (29.3%), 47 had sufficient vitamin D (62.7%), and 2 had toxic vitamin D levels (2.7%), which demonstrate that there were high statistical significance difference between case and controls regarding to 25(OH)D with p-value <0.001. Although there was high statistical significance difference between cases and controls regarding to BMI and AST with p value <0.05, but there was no statistical significance difference between case and controls regarding to age, sex and ALT. Conclusions: Low 25(OH) vitamin D levels are associated with the presence of NAFLD. X |