الفهرس 
THROMBOPOIESISOnly 14 pages are availabe for public view
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Abstract
To establish normal values for platelet paramet~ s
among the Egyptian population, 250 normal individuals WE’ e
recru1ted from those attending Ain Shams Special1z j
H~spital for minor surgical operatio~s and from laborato y
personr1el. Platelet count range was 154-451 x 109/L Wl h
mean 287.2 ± 63.9, MPV range 7.5-11.5 fl with mean 8.98 ~
0.9, Pet range 0.151-0.483 with mean 0.255 + 0.050 and P ’·J
range 15.2-18.8 with mean 16.7 + .0.62.
The relation between p 1 ate 1 et count and MPV was a nor,linear
one, so using the two parameters a nomogram utilizi g
our reference group was deduced.
A direct linear relation was found between the platel ’
count and Pet. But no relation was found between platel t
count and POW, and between MPV and POW.
For the purpose of evaluating the performance of the
plus Jr, the following studies were done:
1- Accuracy: 70 whole
ranging between 6 x
blood samples with platelet court
109/L- 990 x 109/l. Good correlatir 1
was found between manual and automated platelet counts t
different values where r = 0.98.
r.r·nur) 1 T: Thr nmbocytopon i a:
tested, their mean MPV was below normal control and did 1ot
fit our reference nomogram, on the contrary to most o 1er
stud1es. Th1s is part 1 y due to presence of p 1 ::.c. I et
fragments 1 n the acute phase of the disease and part 1 y ’ue
to decreased number of cells. S0, platelet parameters ••re
not useful in that disorrjer.
As to hypers~lenism again our MPV was higher than ~ st
of the studies, but did fit our reference nomogram. This 1ay
be due to the difference in. the duration of the d i sr se
between our group and others. Prolonged hyperspler ·,sm
produces increased ploidy of megakaryocytes in the ’Jne
marrow with a resultant increase in MPV of platelets.
Patients receiv1ng chemotherapy had found to have a ow
MPV ( ”7 ’)
’ ’. + 0.5) which started to rise before or with !:he
r1se in platelet count indicating marrow recovery.
As 1n patients receiving irradiation their MPV as
Slgnlflcantly below normal and did not fit our referr ce
c:urve.
As Lo paLIC>IltS With SC>PSlS (9 patients), their MPV las
sign1ficantly higher than that of the control (p<0.05) ut
the valu~s fit our nomogram. POW was also increased than he
c·ontrol. Group III: Hematological diseases:
In patients with thalassaemia minor- (40 cases), the :PV
was s 19111f. i cant l y sma 11 er than that of the control, but n ’st
of the cases fitted our nomogram as their platelet nur er
v-Jo1~-:. t1 1 lJ~a-tr· U1i1n th11 contro 1.
The level of MPV is therefore variably dependent on
whether folate deficiency is present (resulting in increE ed
MPV) or m1nor hemolysis 1s predominant (resulting in
rncreased platelet count and decreased MPV).
differer1t from that of the co~trol.
PDW was ot
Again in iron deficiency anemia, platelet count as
significantly higher than the conti-ol (may be due to chrc•ic
blood loss), MPV was within normal but POW was significan ly
higher than the control.
-Group IV: Thyroid disease: (20 patients), their MPV ·as
significantly higher than the control (p<0.05) but he
values were within our reference nomogram, which may be ue
t.o r>rAc.oncr> nf ;>ntihodies directed to rlatelets w; rn
Graves 1 disease.
To test for functional utility of platelet paramete 3,
39 pat1er1ts with mean platelet count 284 ± 294.3 and r an
MPV 9.1 + 2.1 wer-e studied for platelet aggr-egation v. th
ADP. A l1near corr-elation was found between MPV and plate et
\ platelets are definitly more active than smaller ones. No
correlat1on was found between platelet count and plate Jt
aggregation%.