الفهرس 
Voltage-gated calcium channels
Results and DiscussionOnly 14 pages are availabe for public view
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Abstract
The objective of this research project is to design,synthesize and evaluate novel 1,4-dihydropyridines (DHPs) as calci um channel antagonist using the high K+ contraction of guinea-pig ileal longitudinal smooth muscle. The synthesized compounds were nifed ipine analogues where ortho-nitrophenyl group of nifedipine was modified to be ortho or meta chlorophenyl substituent. The symmetrical analogues (series I,3a-k) were synthesized by condensing two moles of alkyl acetoacetate and one mole of ammonium acetate with one mole of either ortho or meta chlorobenzaldehyde, in a classical Hantzsch synthes is,whereas the asymmetrical analogues (Series II, 6a-n) were synthesized by a modified Hantzsch reaction, that involved, condensation of e ither ortho or meta chlorobenzaldehyde,and alkyl acetoacetate with alkyl 3-aminocrotonate