الفهرس 
Extrensic blood clotting system:
NATURALLY OCCURRING INHIBITORS OF BLOOD COAGULATIONOnly 14 pages are availabe for public view
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Abstract
In this work, the fibrinolytic mechanism was studied in 30 diabe tics before and
after control of hyperglycemia. These diabetic patients were dev ided into two main groups:
A) 20 were adult onset diabetics without complications and under different lines
of treatment:
J. 10 patients were treated by oral hypoglycemics.
2. 10 patients were under insulin therapy.
B) 10 were diabetics with different complications and under insulin therapy.
The fibrinolytic study included the following tests: Bleeding time.
Whole blood coagulation t1me. Thrombin time.
Fasting serum glucose. Plasma fibrinogen level. F.D.Ps.
Hess test.
The results in adult onset d’abetics without complication show tendency to
hypoftbrinolytic state as e\ idenced by:
high plasma fibrinogen level. Short thrombin time.
The amount of F.D.Ps did not change from the normal.
Both bleeding and coagulation times were shorter than normal. Fasting serum glucose
was higher than normal.
Hess test did not change from normal.
On statistical comparison with the control results:
Both plasma fibrinogen level and fasting serum glucose show highly significant
increase.
Both thrombin time and coagulation time show highly significant decrease.
The bleeding time shows an insignificant increase.
The amount of F.D.Ps. show an insignificant decrease.
In diabetic group with different complictions, the same findings were seen but, with
more pronounced change. However, statistical comparison revealed an insignificant difference.
The demmished fibrinolytic activity may be due to the increase l!l the level of
plasma plasmin inhibitors and the decrease in the level of plasminogen activators.
This does not need special management because most of the drugs used to treat
diabetes are also fibrinolytic stimulators especially oral hypoglycemic drugs.