الفهرس 
Antihistaminic drugs:Only 14 pages are availabe for public view
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Abstract
non-antibiotics antihistaminics mucolytics, antibacterial activity antibiotic - drug combinations, biofilm, efflux pump inhibitor Antihistaminics and mucolytics are widely used for various indications during microbial infection. Hence, in the present study, the antibacterial activity of some antihistaminic drugs belonging to both old and new generations (diphenhydramine, dimenhydrinate, promethazine, triprolidine cyproheptadine, chlorpheniramine and cetrizine and mucolytic drugs ambroxol and bromhexine against one hundred and fifty multiresistant isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis Pseudomonas aeruginosa and Staphylococcus aureus (thirty isolate each) as well as reference strains of each was investigated. Four antihistaminic drugs namely promethazine, cyproheptadine, cetrizine and diphenhydramine showed in-vitro antibacterial activity against multiresistant Staphylococcus aureus isolates with concentrations ranging from 100 to 1000 μg/ml. Only two of these drugs namely promethazine and cyproheptadine showed in-vitro antibacterial activity against different species of multidrug resistant Gramnegative bacterial isolates. Gram-positive bacteria revealed a relatively greater susceptibility to these drugs than Gram-negative ones. On the other hand, the tested mucolytic drugs showed no in-vitro antibacterial activity under the conditions of test.