الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The present study was designed to investigate the relationship between serum resistin level in patients with coronary heart diseases (acute myocardial infarction, unstable and stable angina).
This study included a total of 75 subjects: 40 patients with cardiac problems were chosen from the intensive care unit. 20 patients were chosen from the out patients clinic of cardiology department of Minia University hospital and 15 healthy subjects as controls in the period extending from March 2009 to July 2009. They were classified into four groups:
Group I: (acute myocardial infarction).
Twenty patients (14 males and 6 females) their ages ranged from 50-72 years.
Group II: (unstable angina).
Twenty patients (12 males and 8 females) their ages ranged from 45-75 years.
Group III: (stable angina).
Twenty patients (13males and 7 females) their ages ranged from 44-69 years.
Group IV: (Controls).
Fifteen healthy subjects (8 males and 7 females) their ages ranged from 56-72 years.
All included patients and control subjects were subjected to full history taking, complete
clinical examination, ECG, Echocardiogram and laboratory investigations including
complete blood count (CBC), lipogram (total Cholesterol, serum triglycerides, LDL
and HDL), creatine kinase- isoenzyme (CK-MB), high sensitive C reactive protein
(hsCRP) and serum resistin.
The results of the present study showed a significant increase in the inflammatory
markers (white blood cells and hsCRP) in myocardial infarction and unstable angina patients when compared with controls (P value < 0.001 and 0.011) and (P value < 0.0001and 0.0001 respectively).
The results of the present study showed a significant increase in CK-MB in patients
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Summary
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groups (myocardial infarction, unstable angina and stable angina) when compared with
controls (P value <0.0001, <0.0001 and 0.002 respectively) and a significant increase in myocardial infarction patients when compared with unstable angina and stable angina
patients (P value <0.0001). There was a significant increase in unstable angina patients when compared with stable angina patients (P value <0.0001).
The results of the present study showed a significant increase in serum resistin in patient groups (myocardial infarction and unstable angina) when compared with controls
(P value <0.0001 and 0.0012 respectively). While there was no significant difference in serum resistin in stable angina when compared with controls (P value=0.2). Also showed a significant increase in serum resistin in myocardial infarction patients when compared with unstable angina and stable angina patients (P value = 0.0063 and <0.0001 respectively) and significant increase in serum resistin in unstable angina when compared with stable angina patients (P value = 0.044).
The present study showed a significant positive correlation of serum resistin to age in myocardial infarction group (r=0.53 and p=0.017).
The results of the present study showed no correlation of serum resistin with total cholesterol, serum triglycerides, low density lipoproteins and high density lipoproteins.
The results of the present study showed that there was a significant positive correlation of serum resistin with white blood cells in (myocardial infarction and unstable angina
groups) (r=0.51 and p=0.021) and (r=0.53 and p=0.016) respectively. While there was no significant correlation of serum resistin to white blood cells in stable angina group (r=0.34 and p=0.14), and a positive significant correlation with hsCRP in {(myocardial infarction, unstable angina and stable angina groups)} with (r=0.59 and p=0.002), (r=0.57 and p=0.009) and (r=0.49 and p=0.03) respectively.
The present study showed a significant positive correlation of serum resistin with CK-MB in patients with {(myocardial infarction, unstable angina and stable angina groups)} (r=0.62 and p<0.0001), (r=0.58 and p=0.006) and (r=0.56 and p=0.01) respectively
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Conclusion& Recommendations
Conclusion
from the present study we can conclude the following:
1) Resistin could be used as an inflammatory marker for myocardial infarction.
2) Resistin could be used for follow up of cases of unstable angina. where increase in serum resistin may be used as indicator for possible development of myocardial infarction.
3) Setting reference value for serum resistin should be done as its value differs according to age.