الفهرس 
Oxygen cascade
Patients and methodsOnly 14 pages are availabe for public view
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Abstract
Traditionally, suxamethonium has been the neuromuscular blocking drug of choice for rapid sequence induction of anaesthesia. However, its use may be associated with several side-effects including myalgia, which is caused by muscle fasciculations. These muscle fasiculations produce an increase in whole body oxygen consumption Increased oxygen consumption following suxamethonium is one of the factors that may have a major effect on the time to oxygen desaturation following apnoea, during induction of anaesthesia. In comparison, studies have shown that non-depolarizing neuromuscular blocking drugs do not alter oxygen consumption in anaesthetised patients, So rocuronium, a rapidly acting non-depolarising neuromuscular blocking agent, has been suggested as an alternative to suxamethonium for rapid sequence induction of anaesthesia.
Therefore, the effect of using suxamethonium vs rocuronium on the onset of oxygen desaturation was investigated during rapid sequence induction of anaesthesia.
Sixty patients were randomly allocated to one of two groups. Anaesthesia was induced with lidocaine 1.5 mg.kg−1, fentanyl 2 μg.kg−1 and propofol 2 mg.kg−1, followed by either rocuronium 1 mg.kg−1 (Group R) or suxamethonium 1.5 mg.kg−1 (Group S).
The result of this study showed that the time to reach SpO2 of 95% was significantly shorter in Group S than in Group R.