الفهرس 
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Abstract
Saccharin (systematic name; 1, 2-benzisothiazol-3(2H)-one 1,1-dioxide) is widely used as an artificial sweetener. Thechemistry of saccharin has attracted attention because of its suspected carcinogens’ nature [1-3].Metal complexes of saccharin may also have relevance to the understanding of its human metabolism[4].Saccharin was an important discovery, especially for diabetics. Saccharin goes directly through the human digestive system without being digested. It does not affect blood insulin levels, and has effectively no food energy [5].
The saccharin molecule contains a set of donor atoms that are able to bind metal ions. Studying the coordination nature of saccharin and determining the binding site(s) to metal ions is perhaps a key to understand the bioinorganic chemistry of saccharin. A lot of saccharin binary andternarycomplexes have been reported and investigated [6-12].The data obtained indicate that saccharin acts either as a monodentate anion, coordinatingvia the nitrogen or carbonyl oxygen atoms, or as a bidentate ligand using both donoratoms. A different mode of coordination has also been reported for saccharin [13] in thecomplexes [M (sac)2L2) xH2O(M= Cu (II) or Co (II), L= H2O or pyridine, X= 1, 2 or 4].The octahedral coordination sphere associated with these complexes contains two carbonyl groups of two saccharin molecules and two sulphonyl groups of two other saccharin molecules. The remaining sulphonyl and carbonyl groups of each molecule coordinate with other metal ions to give a polymeric structure with a molar, metal: saccharin ratio of 1:2. The remaining two octahedral positions are occupied by two pyridine molecules or two N-H groups of two saccharin molecules.
Saccharin sodium salt has thus far been used as a non-caloricsweetener[14], which is said to be five hundred timesassweet as sugar. Saccharin has long been suspected to be involved in the induction of cancer, thus, the salts and complexes of saccharinnitranionhave been extensively studied[14].
Saccharin is one of the cyclic imides commonly used as a sweetening agent. Mainly due to the effectiveness of saccharin andits metal complexes in biological systems.Namely, the chemical, structural and spectroscopic properties and especially physiological.