الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Chronic liver disease is considered an important health
problem in Egypt. The overall prevalence of schistosomiasis
in Egypt approaches I 0%.
Bleeding is usually a dramatic complication of liver
disease and associated with high mortality. Despite extensive
studies focusing on such bleeding diathesis, it continues to
provide a fruitful area for research and -controversy ( Lo~f:y,
1993).
This study was carried on 54 patients with chronic liver
disease, aiming to explore relation between platelet function
defects and liver disease. The study included 20 volunteers
subjects as a control group. All patients and control group
were subjected to :
Full clinical examination and history taking
stressing the history of bleeding episodes.
Full lab. chemistry study including CBC, ALT.
AST, PT, bleeding time, hepatitis markers (B and C), platelet
indices :
Platelet aggregation tests using ADP.
Platelet factor 4 (PF-4) assay.
Abdominal ultrasound.. ·.., .· ’ ’;·i( i 1
Antibilharzial antibodies.
Rectal snip.
Liver biopsy were done to some patients (21) for
some technical difficulties.
Introauction & Jlim of tlie ’Work. [2)
Patients were classified into group A, 8 and C
according to child-classification and into mixed bilharzia!
hepatitis and posthepatitic cirrhosis. Lastly according to
bleeding tendency into hematemesis, bleeder and non-bleeders.
Aim of the Work :
The aim of the present study focuses on platelet
dysfunction in liver disease mainly platelet aggregation
response and platelet secretion to discover if any existing
relation is found between bleeding diathesis complication and
platelet abnormalities.