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Abstract A total number of 120 Nile catfish (C/arias gariepinus) with a body weight ranged from 90- 115 gm were used. Fish were obtained from the ponds of the Central laboratory of Aquaculture Researsh, Abbassa, Abo-Hammad, Sharkia, Egypt. Fish were apparently healthy and free from skin lesions or external parasites, and maintained in glass aquaria (50x40x150 cm capacity) having 180 litres of dechlorinated tap water. Each aquarium provided with an aeriator, thermostatically controlled with heater and thermometer. Fish were acclimatized for two weeks to laboratory environment. They were fed 3 times daily on a basal diet contained 35.4 % crude protein. The amount of food per day was 3 % of fish body weight. The experiment was conducted for two weeks The fish were divided into four equal groups as following: l ” group: kept as control. 2nd group: were exposed to 112 LC50 of roundup (14.5 mg/L). 3rd group: were exposed to 112 LC50 of Stomp (420 ug/L). 4th group: were exposed to a combination of 112 LC50 of both roundup and Stomp. The study was carried out to elucidate the immunotoxicity, genotoxicity and oxidative stress modulatory effects of commercial formulations of glyphosate (Roundup) and |