الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Introduction and ff_im of tlie Worl(
•
INfRODUCTION
Beta thalassemia major is the most common chronic hemolytic disorder in Egyptian children
(Sabry,1973).
All the patients are dependent on regular blood transfusion to prolong their life expectancy,
prevent profound weakness and cardiac decompensation caused by severe progressive
anemia.
Haemosidersois, can develop from repeated blood transfusion and enhanced mucosal iron
absorption in these patients. This can impair both cardiac and respiratory functions (cardiac and
pulmonary sidersosis) (Awaad et al.,1975).
Khalifa et al. (1989), studied the depressent effect of myocardial siderosis on cardiac
functions and found that it was more marked in spleenectomized and hypersplenic
patients due to increased tissue stores of iron in these patients.
There are conflicting reports about the state of lung function in patients with thalassemia
major. While Cooper et al. (1980); Fun ..!!...LtJ:!, (1986), Baccalo et al. (
an Factor et al.
”- c;4- (]JJBti), reported a mild restrictive lung disease,
· · others including Keens et al. (1980) and Hoyt et
al. (1986), reported mild decrease in expiratory flow rates.
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Introduction ant! lf_im o-f tfze Worli
AIM OF THE WORK: ’S
The aim of this thesis was to study th k
possible abnormalities in pulmonary functio ··Q _
Egyptian children with chronic hemolytic anemia dv’
· and t_ryHtg to correlate the obtained results to the
f duration of illness, cumulative volume of
J transfusion (namely the presence or absence of
hypersplenism), iron overload and effect of spltnectomy.
This work will be limited to cases with 15- thalassemia major, being the commonest cause of
chronic hemolytic anemia in Egypt.
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