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Abstract Interest m the interactions between the central nervous system (CNS) and the immune system date back to Aristotle who hypothesized a connection between physical health and mood. During the mid 1950’s, Sclye demonstrated a clear relation among brain activity, endocrine organs, and immune function. In 1964 this field was first referred to as Psycho-immunology, later amended to J>rycho-neuro-immunology: the study of interaction of consciousness, the brain and the CNS, and the immtme system (Stoudemire and McDaniel, 1995). In 1975, Adcr described the basic factors of psycho-neuroimmunology as follows: • Nerve endings have been folllld in the tisSlles of the immune system. The central nervous system is linked both to the bone marrow and the thymus, where immune system cells are produced and developed and to the spleen and the lymph nodes, where those cells are stored. • Changes in the CNS (the brain and the spinal cord) alter immune responses and triggering an immune response alters the CNS activity. Animal experiments show that damage to different parts of the hypothalamus can either suppress or enhance the allergic type response. • Changes in hormone and ncurotran.,mittcr levels alter immune responses and vice versa. The stress hormones generally suppress immune responses, but other hormones, such as Growth hormone, also seem to affect immunity. • Lymphocytes are chemically responsive to hormones and neurotransmitters. Immune system cells have receptors that are |