الفهرس 
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Abstract
New two simple and accurate spectrophotometric methods have been developed for the determination of aripiprazole (ARP), sulpride (SLP), amisulpride (AMS) and pizotefin (PZT) in pure forms and pharmaceutical formulations. The first technique is presented for the assay of aripiprazole (ARP), sulpride (SLP) and pizotefin (PZT) in bulk drugs and in pharmaceutical formulations using N-bromosuccinimide (NBS) and three dyes (methyl orange, amaranth and indigo carmine) as reagents. The methods involve the addition of a known excess of NBS to drug in acid medium, followed by determination of unreacted oxidant by reacting with a fixed amount of methyl orange and measuring the absorbance at 522 nm (method A), amaranth and measuring the absorbance at 507 nm (method B) or indigo carmine and measuring the absorbance at 610 nm (method C). In all three methods, the amount of NBS reacted corresponds to the amount of drug and the measured absorbance is found to increase linearly with the concentration of drug which is corroborated by the correlation coefficients of 0.9992- 0.9999. The systems obey Beer’s law for 0.1-3.8, 0.2-4.6 and 0.2-4.4 μg mL-1for ARP, SLP and PZT, respectively. In the second technique, we investigate the development of spectrophotometric methods for determination ARP, AMS and PZT based on the formation of charge-transfer complex of the studied drugs with π-acceptors (p-CLA and TCNQ) in acetonitrile. Beer’s law is obeyed in the concentration ranges 5.0-160 and 2.0-32 g mL-1 using p-CLA and TCNQ, respectively. The correlation coefficient was ≥0.9992 with a relative standard deviation (R.S.D.) of ≤ 1.82. The limits of detection and quantification are also reported. Intra-day and inter-day precision and accuracy of the methods have been evaluated. The proposed methods were successfully applied to determine the studied drugs in their formulations without any evidence for interference from pharmaceutical additives and the results were statistically compared with those of the reference methods by applying Student’s t-test and F-test. The results were in good agreement with those obtained by the reference methods. The accuracy of the methods was further ascertained by performing recovery studies via standard-addition method. The proposed methods can be confidently applied for quality control and routine analysis of the studied drugs.