الفهرس 
Down syndromeOnly 14 pages are availabe for public view
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Abstract
Down syndrome is the most common autosomal aberration among the pediatric practice, characterized by presence of an extra copy of genetic material on the 21 chromosome. The rise in average maternal age could bring with it an increase in the number of pregnancies affected by DS. Nondisjunction constitutes more than 90% of cases, 49% of cases were born to mother older than 35 years. Children with DS have multiple malformation and mental impairment, they have an increased risk of congenital heart disease, GIT anomalies, thyroid disease, hearing and visual disorder, obstructive sleep apnea ,acquired hip dislocation and leukemia.Early diagnosis and proper screening and follow up of these children are of great importance, and referral to specialized clinic is needed. Elevated serum uric acid levels in people with Down syndrome have been reported by many authors, but the origin of this biochemical anomaly is unclear. Some authors attribute this increase to alterations in glomerular filtration, but the formation of uric acid can also occur through the xanthine oxidase system. This work aimed to study the serum uric acid level in children with Down syndrome. This study was done on 40 children, 2-6 years of age, who were divided into two groups: i. Group Ι: included 20 patients who had already diagnosed as Down syndrome according to their karyotyping, from Tanta University Hospital.