الفهرس 
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Abstract
Iron is critical to normal cellular functions that play an important role in metabolic processes. In spite of its requirement in the body, a misbalance in iron homeostasis can be devastating; accumulation of iron has been associated with hemochromatosis and production of free radicals that potentially leads to neuronal damage, lipid peroxidation, and depletion of lipid soluble antioxidants in testicular tissue results in disruption of spermatogenesis. Iron administration caused disturbances in all the measured parameters represented as a significant increase in Serum Gamma-glutamyle transferase (γGT) activity, ferritin level, iron concentration and iron concentration in both brain & testis. While as a significant decrease in White Blood Corpuscles (WBCs) count, haematocrit percent, serum transferrin level and serum zinc concentration. Also causes a decrease in brain concentration of dopamine, serotonin and nor epinephrine. On the other hand, Treatment with melatonin prior to the iron intoxication reduced the incidence of these pathological changes in the brain and testicular tissue and showed revealed marked amelioration in comparison with the iron- treated group.In Conclusion: The present study demonstrated that the administration of melatonin at a dose of 15mg/kg ameliorated oxidative stress and counteracting the deleterious effects of iron overloading in both brain and testis.