الفهرس 
obesityيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Obesity is becoming a significant problem for many countries around the world. Rates of obesity have reached epidemic levels, and both developed and developing countries are
now affected. It has more doubled in prevalence in the last 30
years. The global prevalence of obesity has increased
considerably in the last decade. According to estimates of the
world health organization(who),80 % of the world population was
primarily based on traditional methods of healing which use
medicinal plants and folk knowledge. Phytotherapy is the
treatment and prevention of diseases using plants, plants part such
as fruits, flowers, leaves, and roots or mixtures of them, these
plants called medicinal plants, or herbs.
The aim of recent studying the effect of some plant
materials and herbs which were suggested in folk medicine for
treating obesity, after knowing their active constituents and their
biological activities, using experimental animal (Rats).
This study used species of herbs and plants, which are used
individuals and as mixture of them to form photogenic diet for
treatment obesity. All herbs and plants were milled by using a
precession mill to give a powder and were kept in plastic bags in
a cool and dry location for using, all herbs and plant are best in a
cool, dry and dark location to reduce oxidation of their contents. Thirty two female albino rats, each weighing 210±59g, eight
weeks age were used this investigation.
All rats were the control diet for 5 days before beginning of
the experiment for adaptation.
The rats were divided into (8) groups of (4) rats each with
similar total weigh and were housed as twice in the cages.
All obese rats were fed the experimental diet (basal diet) for
4 weeks without or with herbal powder, and there is one group
continues with high fat diet plus herbal mixture. The rats divided
into the flowing group:-
- Group 1: Rats fed on basal diet as negative control.
- Group2 :Ratsfed on basal diet with fat to as positive control.
- Group3: Rats fed on basal diet with cake with (2.5%) chicory.
- Group4: rats fed an diet with cake supplemented with (5%)
chicory.
- Group5: rats fed on diet with cake supplemented with (2.5%)
senna.
- Group6: rats fed on diet with cake supplemented with (5%)
senna.
- Group7: rats fed on diet with cake supplemented with (10%)
myrrh. Group8: rats fed on diet with cake supplemented with (1.5%)
myrrh.
Biological evaluation of the different diets was carried out
by determination of body weight gain (BWG%), food efficiency
ratio (FER). at the end of the experiment, Blood samples were
collected for using to determination of the following parameters:-
serum lipids / uric acid / creatinine / urea / glutamic oxaloacetic
transaminase (ALT ) and glutamic pyruvic transaminase(AST) /
Alkaline phosphatase (ALP)
The Kidney, spleen, lunge, liner and heart with aorta of each
rat were removed, cleaned in saline solution and dried then
weighed separately for histpathological examination.
The data were analyzed using a completely randomized
factorial design SAS (1988).
The results were out put as following:
1) Biological evaluation
The control negative was point to very high significant
differences p< 0.01, when compared with control positive and all
other groups for initial weight .Regarding to final weight, the
diets were cosisited Cichorium intybus (chicory), continue high
lipid, commercial, herbal mixture were revealed to very high
significant differences p<0.001and Cassia occidentalis (Senna),
Commiphora myrrh (myrrh) p< 0.05 comparing with control
positive .The control negative and the diets were cosisited ,
Cichorium intybus (chicory), Commiphora myrrh (myrrh),
continue highlipid were refered very high significantdifferences
p<0.001and Cassia occidentalis(Senna)., commercial p< 0.05
comparing with control positive for food intake .Finally as for
percentage of weight gain and food efficiency ratio all groups
showed very high significant differences p< 0.001 comparing
with control positive while no significant differences between
control positive and control negative .
2) Serum Lipid
The control negative and the diets were cosisited Cichorium
intybus (chicory), continue high lipid, commercial, herbal
mixture, Cassia occidentalis (Senna)., Commiphora myrrh
(myrrh) were referred very high significant differences p< 0.001
comparing with control positive for total lipid, triglycerides, LDL
,VLDL, Cholesterol except between cholesterol the degree of
differences at p< 0.05 .As for HDL no significant differences
between other group and control positive. The diets were
consisted showed very high significant differences p< 0.001 and
Cichorium intybus (chicory), commercial p< 0.05 comparing with
control positive for phosphlipid and no significant differences
between other group and control positive Regarding to heart weight control negative and the diets
were cosisited Cassia occidentalis (Senna), continue highlipid
showed high significant differences p< 0.001 and Cichorium
intybus(chicory), Commiphora myrrh (myrrh), commercial
p<0.05 comparing with control positive .As for kidney weight the
diet was consisted Cichorium intybus (chicory) refered high
significant differences p < 0.001and herbal mixture p<0.05
comparing with control positive while no significant differences
between control negative, Cassia occidentalis(Senna) ,
Commiphora myrrh (myrrh), continue high lipid, commercial and
control positive .
The control negative and the diets were cosisited Cichorium
intybus (chicory), continue high lipid, commercial showed high
significant differences p<0.001 and Cassia occidentalis(Senna) ,
Commiphora myrrh (myrrh) p< 0.05 comparing with control
positive for liver weight .As for lung and spleen no significant
differences between all groups and control positive .
4) Liver Function
Regarding to ALT no significant differences between all
groups and control positive. The diet was consisted herbal
mixture showed high significant differences p< 0.05 comparing