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Abstract The goal of the present study was to assess the relationship between H-pylori infection and insulin resistance. For this purpose , 90 patient with dyspeptic complaints were subjected to the following: • Thorough history taking. • Thorough clinical examination. • Laboratory investigations: • Complete blood count (CBC). • Liver profile . • Kidney function tests . • Fasting serum insulin . • Calculation of insulin resistance index(HOMA-IR) through the formula (HOMA-IR) = fasting serum insulin (µu/ml) × fasting plasma glucose (mg/dl). • Radiological investigations: - Pelvi abdominal ultrasonography was done to all patients included in the study for evaluation of the liver ,spleen, gall badder and kidney. • Upper gastrointestinal endoscopy: Two antral biopsies were taken by a biopsy forceps for histopathological examination. • Histopathological examination of the antral biopsies: H&E (Haematoxylin-Eosin) and Giemsa Stain were used for detection of H-pylori infection. Patients were divided into two groups according to the presence of H-pylori infection: • group A: H-pylori positive patients. • group B: H-pylori negative patients. H-pylori positive patients were 51patient (56.7 %) and H-pylori negative Patients were 39 patient (42.3%) Regarding clinical and endoscopic findings there was no difference between H- pylori positive and negative cases. As regard, age and sex there was no difference between H- pylori positive and negative cases. HOMA (IR) was higher in H-pylori positive cases than in H-pylori negative Cases as it was 3.7 in H-pylori positive while it was 2.3 in H-pylori negative cases with a high statistically significant difference. The results of this study revealed that there is an association between H-pylori infection and insulin resistance. |