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العنوان
Study of the association between h -pylori infection and insulin resistance /
المؤلف
Kandil, Alaa Eldin Ibrahim.
هيئة الاعداد
باحث / علاء الدين ابراهيم قنديل
مشرف / عاطف حامد عسل
مشرف / مجدى عبد الموجود جاد
مناقش / نشوة محمد عمارة
مناقش / محمد سعيد مصطفي سليمان
الموضوع
Infectious diseases.
تاريخ النشر
2011.
عدد الصفحات
100 p. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكبد
تاريخ الإجازة
1/1/2011
مكان الإجازة
جامعة بنها - كلية طب بشري - Hepatology,Gastroenterology and Infectious Diseases
الفهرس
Only 14 pages are availabe for public view

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Abstract

The goal of the present study was to assess the relationship between H-pylori infection and insulin resistance. For this purpose , 90 patient with dyspeptic complaints were subjected to the following: • Thorough history taking. • Thorough clinical examination. • Laboratory investigations: • Complete blood count (CBC). • Liver profile . • Kidney function tests . • Fasting serum insulin .
• Calculation of insulin resistance index(HOMA-IR) through the formula (HOMA-IR) = fasting serum insulin (µu/ml) × fasting plasma glucose (mg/dl).
• Radiological investigations: -
Pelvi abdominal ultrasonography was done to all patients included in the study for evaluation of the liver ,spleen, gall badder and kidney.
• Upper gastrointestinal endoscopy:
Two antral biopsies were taken by a biopsy forceps for histopathological examination.
• Histopathological examination of the antral biopsies:
H&E (Haematoxylin-Eosin) and Giemsa Stain were used for detection of H-pylori infection.
Patients were divided into two groups according to the presence of H-pylori infection:
• group A: H-pylori positive patients.
• group B: H-pylori negative patients.
H-pylori positive patients were 51patient (56.7 %) and H-pylori negative
Patients were 39 patient (42.3%)
Regarding clinical and endoscopic findings there was no difference between H- pylori positive and negative cases.
As regard, age and sex there was no difference between H- pylori positive and negative cases.
HOMA (IR) was higher in H-pylori positive cases than in H-pylori negative
Cases as it was 3.7 in H-pylori positive while it was 2.3 in H-pylori negative cases with a high statistically significant difference.
The results of this study revealed that there is an association between H-pylori infection and insulin resistance.