الفهرس 
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Abstract
the unbalanced globin chain synthesis in severe
B-thalassemia produces extensive destruction of immature and
mature red cells and the resulting anemia provokes a compensatory
hyperplasia of the erythroid marrow which is largely ineffective.
Employing ferrokinetic techniques, rates of erythroid precursors
proliferation have been estimated at about 10 - 20 times basal level
in severely anemic patients (Cazzola et al., 1987). Therefore, the
problem of severe ~-thalassemia is not only one of anemia but the
combined effect of anemia and massive enlargement of erythroid
marrow.
Regular blood transfusions are effective in suppressmg
erytb..roid marrow expansion in severe ~-thalassemia but still the
optimal transfusion regimen is a controversial issue.
Cazzola et al. (1997) reported that moderate transfusion
regimen at pretransfusion levels of 9 grn/dL may reduce iron loading
in 13-thalassemia major without producing excessive expansion of
erythropoiesis.
Serum transferrin receptor assay is now considered one of
novel accurate tools for measuring erythropoiesis in clinical setting
[Cazzola and Beguin, 1992)