الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
The relation of allergy to autoimmunity is an
interesting new field of research. Autoantibodies
to IgE can be detected in sera of individuals with
atopic disease and their functional properties are
a subject of debate. Antibodies have been found
that either trigger or inhibit mediator release
from basophils, that enhance or inhibit binding of
IgE to the low affinity IgE receptor and either
stimulate or inhibit human IgE synthesis (Stadler,
1994). Based on such in vitro experiments, it
seems that in vivo autoantibodies exist that
either neutralize IgE or have no effect on IgEmediated
clinical events.
Shakib and associates (1993) hypothesized
that circulating anti-IgE antibodies could
potentially enhance IgE synthesis and facilitate
the removal of IgE-allergen complexes by
triggering IgG effector function pathways. Another
study revealed that asthma patients have
significantly elevated levels of IgGl and IgG4
anti-IgE antibodies which have an ability to
trigger basophil histamine release (Shakib et al.,
1994). Stadler (1994) postulated that anti-lyE
autoantibodies may hide IgE as for example in
those bee sting allergic individuals where
specific IgE may not be detected but can be hidden
within immune complexes suggesting that the
biological activity of IgE is preserved. A similar
Phenomenon may exist in allergic individuals.
This study is aimed to evaluate the relation
between allergy and autoimmunity through the
estimation of circulating immune complexes in
Introduction and Aim nf The Wm-k (I)
asthmatic children with respect to diseuse
severity and treatment received. The rel~tion of
their levels to total serum IgE and other
parameters of disease activity are aimed to be
outlined. This field may provide alternative or
complementary therapeutic modalities in resistant
cases of chi ldhom.l asthmu.