الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
PD is a neurodegenerative disorder that currently affects about 1–3% of the population over 50 years of age affects 5% of the population over 65. Brain regions involved in motor function, including the striatum, substantia nigra and ventral tegmental area are reduced in size in PD patients as a result of the degeneration of synapses and death of dopaminergic neurons. OBNSCs, with the capacity to self-renew and to produce the major cell types of the brain with autologous property, exist in the developing and adult CNS. Their exact function and distribution is currently being assessed, but they represent an interesting cell population which may be used to study factors important for the differentiation of neurons, astrocytes and oligodendrocytes. There have been reports recently of the effects of NSC transplantation that attempt to obtain functional recovery from CNS damage and recent evidence suggests that NSCs may be a suitable source for the treatment of neurological diseases such as Parkinson’s disease. With an eye towards the development of NSCs replacement therapies, it is important to investigate the migration profile of Neurotrophic-differentiated neurons and monitor the success of subsequent integrations into existing neuronal circuitries.The present study aims at gaining more insight into the functional role of the Neurotrophic on neurogenesis. Data indicate that NGF particular may play a pivotal role in PD and the control of NSCs proliferation and differentiation. A promising approach for the treatment of PD is the application of NGF as a potential remedy. However, delivering NGF to the brain in an appropriate manner is still challenging because NGF does not cross the blood-brain barrier when applied peripherally. Even NGF causes intolerable side effects (including pain) if administered into the brain ventricular system. In conclusion, the present study demonstrated that human OBNSCs expressing NGF ameliorate the cognitive deficiencies associated with 6- hydroxydopamin-induced lesions in PD model rat via increased NGF production. These results indicate that human OBNSCs expressing NGF are promising candidates for the cell-based gene therapy for PD patients.