الفهرس 
Introduction
Viral EncephalitisOnly 14 pages are availabe for public view
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Abstract
Viral infection of the central nervous system (CNS) most often leads to meningitis, meningoencephalitis, or encephalitis, in descending order of frequency. Encephalitis is inflammation of the brain parenchyma, manifest by neurologic dysfunction (eg, altered mental status, behavior, or personality; motor or sensory deficits; speech or movement disorders; hemiparesis; or paresthesias) (Thompson et al., 2012).
Neuron-specific enolase (NSE) is a glycolytic pathway enzyme, localized predominantly in neuronal cytoplasm (Selakovic et al., 2005).
It is a useful biochemical marker for brain-tissue damage (An Tao et al., 2009).
The aim of this study was to assess the serum and cerebrospinal fluid level of the neuron- specific enolase ( NES) and its relation to the severity of neurological impairment in children with viral encephalitis.
The study was carried out on 50 subjects who were classified as follows:
Group 1: consisted of 30 patients with viral encephalitis selected from the pediatric inpatient department, Children’s University Hospital, Minia University, during the period from July 2012 to September 2012. They were 11 male and 19 female whose age ranged from 4 to 31 months.
Group 2: The control group consists of 20 apparentaly healthy children, age and sex matched to the diseased group, they were 12 male and 8 female whose age ranged from 4 to 26 months.
The studied patients were subjected to the following:through history taking, Complete physical examination, routine CSF analysis, and assessment the level of serum and CSF level of neuron specific enolase (NSE), radiological investigation include brain CT, assessments of Glasgow Coma Scale score at the time of lumbar puncture and Glasgow Outcome Scale score at the time of patient discharge or death. In addition serum NSE was assessed in the control group.