الفهرس 
Introduction and Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Metabolic syndrome (MetS) is a worldwide problem that affects up to 25% of adult population. It is a constellation of interrelated abnormalities including obesity, dyslipidemia, hypertension, and insulin resistance. However; there is yet no established therapeutic ¬trategy for treatment of MetS. br This work was devoted to investigate the possible effects of some antiinflamatory drugs on FFR. The study included three sets of experiments. The first set evaluated the effect of diacerein (interleukin-1beta inhibitor) and/or metformin on prvention of FFR. To achieve this aim, dugs were administered -#102;-#114;-#111;-#109; the start of fructose feeding and continued for 6 weeks. The second experiment evaluated the effect of etanrecept (TNFα inhibitor) and/or diacerein in treatment of FFR. In this set, the drugs were given for 2 weeks (after induction of MetS). The third set evaluated the effect of montelukast (leukotriene receptor antagonist) and irbesartan (ARB) on prevention of FFR. br The effect of above mentioned drugs on physical parameters (body weight, visceral fat weight, visceral fat weight/ body weight ratio, liver weight/body weight ratio, and kidney weight/ body weight ratio), metabolic parameters (OGTT, fasting glucose, fasting insulin, HOMA-IR , and serum lipids profile) , biochemical parameters (serum creatinine ,urea , creatinine clearance and ALT), oxidative stress parameters (GSH, catalase and lipid peroxides, NO) and inflammatory parameters (uric acid, CRP and TNFα) were evaluated. Additionally, histopathological and immunohistochemical studies were done. br Data of the present study showed that fructose feeding rats caused significant impairment in the physical, metabolic, biochemical, oxidative stress and inflammatory parameters as compared with normal control rats. Hisopathologically, the liver showed hydrobic changes and necro-inflamatory foci. In the kidney, there were cloudy swelling changes. The immunohistochemical staining of liver and kidney tissues for detection of iNOS, eNOS and caspase3 showed strong, mild and strong immunoreactivity, respectively in both liver and kidney. br The results of this study reported that diacerein (50mg/kg/day) solely or in combination with metformin for 6 weeks, etanrecept (0.3mg/kg/3times/week) solely or in combination with diacerein (50mg/kg/day) for 2 weeks, montelukast (10 and 20mg/kg/day) and combination of montelukast (5mg/kg/day) with irbesartan (15mg/kg/day) for 6 weeks prevented the development of MetS in rats. On the light of these results, it is conceivable to suggest that the antiinflammatry agents might represent a potential therapy for MetS. However, further experimental studies are still needed to achieve more definite conclusions.