الفهرس 
Obesity
Type 2 Diabetes Mellitus (T2DM)Only 14 pages are availabe for public view
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Abstract
Obesity has been considered as an inflammatory disease and is highly associated with the development of type 2 diabetes mellitus (T2DM). chronic low-grade tissue inflammation is an important contributor to the etiology of obesity and diabetes mellitus-induced insulin resistance. Adipocytokines and COX-2 play a key role in tissue inflammatory response.Obesity can affect beta cells through the influence of elevated levels of free fatty acids (FFA), and/or through the adipocytokines that are secreted by adipose tissues. The direct effect of FFA, termed lipotoxicity, is leading to apoptosis and reduced insulin secretion. The indirect effect of obesity is thought to be mediated due to dysregulated production or secretion of adipocytokines such as TNF-α, IL-6, Leptin,Adiponectin, Omentin, Visfatin, Adipsin, Resistin, Apelin and Retinol binding protein (rbp4).The present random controlled study aimed to investigate the possible effect of cyclooxygenase (COX-2) inhibition on levels of inflammatory adipocytokines in overweight, obese and non-obese type 2diabetes mellitus. The study comprized 80 diabetic patients recruited from Outpatient Clinics of Internal Medicine Department, Tanta University Hospitals, Tanta, Egypt. Another 40 non diabetic (apparently healthy) subjects enrolled in the present study.