الفهرس 
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Abstract
The hematological and blood biochemical parameters in vivo, using white rats in response to individual injection by washed spore suspension of several indoor fungal spp. revealed that the titer of red blood cells (RBCs) and hemoglobin contents were the most affected parameters by the injected fungal spores, assuming the variable modes by the animal to counterpart the toxicity of these antigens. For A. carbonarius, the amount of RBCs, hemoglobin and hematocrit were strongly affected by the second day of infusion, comparing to the positive and negative controls, assuming the interference with conformational structure of tetrapyrrol ring of heme, or interaction with the iron moieties of the hemoglobin. However, the platelet concentration was greatly increased, compared to positive and negative controls. For A. fumigatus spores, the titer of RBCs, hemoglobin, and hematocrit was slightly decreased by the second day of circulation, with obvious increasing to the amount of platelets, as compared to positive and negative controls. Similar results for decreasing of the concentration of RBCs, hemoglobin, and hematocrit with obvious increasing of the platelets titer were observed for spore suspension of A. petrakii, A. avenaceus and F. oxysporum. As well as, the activity of ALT was clearly reduced after 48 h of injection. However, the corpuscular volume, corpuscular hemoglobin concentration and RBCs distribution were obviously increased.
VII- The antigenic efficacy of several indoor fungal isolates that was determined by measuring of the size of IgG in white rats showed that A. petrakii appeared the highly antigenic, inducing the T- cells of immune system to produce IgG, followed by A. avenaceus, then A. fumigatus and A. carbonarius. The highest IgG titer in response to A. petrakii revealed their unique surface/chemicals structure of polysaccharide of β-glucan/chitin/glycerol proteins, triggering the immunoglobulins of macrophages.