الفهرس 
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Abstract
Candidasis is the most common infection of the oral cavity caused by fungi and C. albicans is the main species related to its development. The genus Candida belongs to the indigenous oral flora of 20 to 40% of healthy subjects, and its pathogenicity is observed in the presence of predisposing conditions such as immunodepression, use of denture or orthodontic appliances and diabetes mellitus. The transformation from the saprophytic to the parasitic form is related to various factors, including not only the virulence of these yeasts, but also host-related variables. Among the host-related factors, the modification of the oral microbiota balance is considered a very important factor.
The effectiveness of ozone against microbiological pathogens is well recognized and ozone appears to be the best agent for sterilization of water. The anti-pathogenic effects of ozone have been substantiated for several decades. Its killing action upon bacteria, viruses, fungi, and in many species of protozoa, serve as the basis for its increasing use in disinfecting municipal water supplies in cities worldwide. In spite of this the use of ozone in medicine has been overlooked because it has been either misused or used without appropriate control. Thus, ozone toxicity has become a matter of debate and anxiety for patients undergoing ozone therapy. So there are two thoughts, one suggests that ozone is definitvely toxic and another believes that ozone can be used as therapeutic agent.
Thus, great efforts have been done to provide a deep and wide scientific foundation for the medical application of ozone, through a number of clinical trials that confirmed the success of ozone therapy and its importance as a scientifically founded new branch of medicine. Ozone can be used medically, intra-arterially, subcutaneously, intramuscularly and externally, also in autohaemotransfusion or a gas introduced into body cavities as well as drops, compresses or liquids for rinsing. It can bring about very good therapeutic results, and regarded as an effective method of treatment. In dentistry, Ozone has been proposed as an alternative antiseptic agent based on reports of its antimicrobial effects in both gaseous and aqueous forms.
This study revealed that:
• Candida albicans produce severe alteration and degeneration of the rat tongue mucosa.
• Tongue mucosa of rats infected with candida albicans treated with ozone oxygen mixture, showed steps towards healing, recovery, and improvement in their histological, immunohistochemical, and ultrastructural patterns.
• Ozone, as a complementary medical approach, may represent an alternative in the treatment of candidiasis and its complications.
• Within the limitations of the study, we suggest that ozone may have an important role in the treatment of resistant candidiasis in tongue mucosa.
• More investigations should be made to evaluate the benificial effect of ozone therapy on candidiasis.