الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 237 |  |  |
| | | from | 237 | | |
Abstract
Osteoarthritis (OA) is a degenerative disease characterized by the progressive degradation of joint cartilage and is accompanied by secondary inflammation of synovial membranes. The present work was devoted to investigate some biochemical changes in knee joint and serum constituents resulting from MIA experimentally induced osteoarthritis in rats and to illustrate the effects of ginger or mushroom supplementation as well as hyaluronic acid treatment against these adverse changes. Forty-eight male rats were divided into eight groups, as a control, ginger, hyaluronic acid, mushroom, osteoarthritic, OA-ginger, OA-hyaluronic acid and OA-mushroom. Serum samples from all rats were used for estimation of total protein level, C - reactive protein, and interleukin-6 concentration. Knee joint tissues from all rats were used for analysis of reduced glutathione, glutathione peroxidase, malondialdehyde, catalase, superoxide dismutase, and total protein level. Injection of MIA that caused osteoarthritis induced an extremely significant elevation in each of reduced glutathione, glutathione peroxidase, malondialdehyde, catalase, superoxide dismutase with a significant fall in total protein level as compared with control group. Treatment with ginger, mushroom and hyaluronic acid resulted in a decrease of these joint constituents with exception of total protein level which was elevated. Ginger and mushroom supplementation in healthy rats caused a significant elevation in reduced GSH and GSHPx than in control but in contrast to HA injection. Similarly total protein levels and catalase activity were higher than in control group by mushroom supplement and didn’t largely differed by ginger or by HA treatment. It is recommended to use such dietary supplements to ameliorate the antioxidant status in osteoarthritis but to a period longer than 4 weeks after onset of the disease.