الفهرس 
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Abstract
Inflammation is a protective body response that develops to get rid of any harmful agent together with the body’s immunity. Non-steroidal anti-inflammatory drugs (NSAIDS), the most commonly used non-selective anti-inflammatory agents; exhibit several side effects upon prolonged use especially in treatment of chronic inflammatory diseases. Side effects maybe minimized by the use of selective inhibitors other than non-selective anti-inflammatory agents. Among the most commonly known targets in inflammation cascade is the PDE4 enzyme. The PDEs family consists of 11 isoforms but in our research our target was the PDE4 isoform and in particular PDE4B subtype due to its critical role in inflammation. Well established drugs acting on such target exhibited serious side effects as nausea, vomiting and diarrhea. In this research, the aim was to design and synthesize novel compounds with potential anti-inflammatory activity especially PDE4B inhibitory activity with minimal side effects.