الفهرس 
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Abstract
Introduction: Hepatocellular carcinoma is one of the most cancer worldwide. The earlier diagnosis of HCC is associated with higher cure rate. Identification of the role of oncogenes and tumor suppressor genes might provide a better understanding of the process of malignant transformation and helps to identify early markers in premalignant lesions.Aim: To evaluate RIZ 1(retinoblastoma interacting zinc finger gene) and RIZ 2 genes in hepatocellular carcinoma and whether they are considered risk factors or associate with the disease.Methods: RIZ 1 and RIZ 2 were tested by RT-PCR in 30 hepatocellular carcinoma cases and 30 chronic liver disease cases as control and their levels were correlated by the homocysteine level.Results: No changes in RIZ 2 expression among groups. Cases of HCC had lower frequency in expression of RIZ 1 compared to controls with statistically significant difference. The negative expression RIZ 1 in cases and controls showed higher level of homocysteine compared to the positive expression with high significant difference. No significant difference was found in relation of age, gender, tumor size and hepatitis status and expression of RIZ 1.Conclusion: The expression of RIZ 1 in tissues has higher specificity than sensitivity. The negative expression of RIZ 1 cannot alone predict the presence of HCC but it is better to be accompanied with serological markers as homocysteine level and others.Key words: Hepatocellular carcinoma; chronic liver disease; Retinoblastoma interacting zinc finger gene; Homocysteine.