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Abstract Obesity which is reaching worldwide unprecedented prevalence in persons of all ages and especially in Egypt develops with accumulation of excess body fat and becomes escorted with a state of chronic oxidative stress. This represents the main cause for morbidity and premature mortality. A clustering of obesity-related sequelae of events exists via hyperglycemia, increased tissue lipid levels and inadequate antioxidant defenses. Thus, the increased rates of free radical formation effecting enzymatic sources within the endothelium, results in chronic inflammation. It may be propagated through a unifying mechanism associated with the development of steatohepatitis. However, although oxidative stress levels are elevated in human obesity, yet these levels are modifiable with various lifestyle changes. Moreover, numerous antioxidants have been recently examined for their protective properties against oxidative damage. |