الفهرس 
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Abstract
Objective: Retrospectively evaluate epidemiologic and clinico-pathologic characteristics and disease free survival in breast cancer patients and relate them to age at diagnosis Patients and methods: This is a retrospective cohort study involving 1128 female breast cancer patients diagnosed and treated at NCI, Cairo in 2003 Results: Mean age at diagnosis was 49.4±11.5 years. Patients younger than 40 years represented 18.4%, 40-<65 years 70.3% and those ≥65 years 11.3%. IDC represented 87.5%. Most of the patients presented with T2 stage (46.9%) and N1 stage (30.8%). Those metastatic at presentation were 16.6% and half of patients presented with TNM stage III (49.9%). Age at diagnosis was not related to T, N, or TNM stage, (p=0.15, p =0.99 and p=0.12 respectively). Patients with negative ER were significantly younger than those with positive ER (46.95 and 50.1 years respectively, p = 0.02). DFS was 60.1 % at 3rd year and 46.4 % at 5th year for all stages (stage I – III). DFS was not related to age, family history of breast cancer, menopausal status, grade of tumor or tumor pathology. On the other hand 5-year DFS was significantly longer in patients with ID component >30% compared to negative ID component, p < 0.001. Large tumor size (T stage), positive nodes (N stage) and advanced TNM stage showed significantly adverse impact on DFS. Patients with negative ER had significantly shorter 5-year DFS compared with those with positive ER, p = 0.03. Systemic adjuvant treatment significantly improved DFS. Breast conservation seemed to give better treatment results compared to MRM, yet not significant. Five-years DFS was significantly shorter in patients who received adjuvant radiotherapy treatment Conclusion: Young age at diagnosis was not found to adversely influence DFS. Tumor size, LN status TNM staging and ER status were significantly associated with DFS. This study demonstrated the late stage at presentation of breast cancer patients which necessitates re-evaluation of the treatment strategies adopted at NCI to improve treatment outcome. Nationwide screening programs are mandatory for breast cancer stage reversal Key words: Breast cancer, prognosis, age at diagnosis, disease free survivalSupervise by.