الفهرس 
Introduction & Aim Of WorkOnly 14 pages are availabe for public view
 |  | from | 165 |  |  |
| | | from | 165 | | |
Abstract
During The Last 2 Decades, Intensification Of Acute Myeloid Leukemia Treatment Has Improved Long Term Survival Of Both Children And Adults Which Now Ranges from 50-60%, However Intensification Of Therapy Is Associated With Increased Toxicity. Aim: To Identify Causes Of Mortality In Pediatric AML Patients, The Incidence Of Bacterial And Fungal Infections And Their Impact On The Outcome And To Analyze The Effect Of Clinical Features And Morphological Classification On The Outcome And Lethal Complications. Patients & Methods: A Retrospective Study On 85 Pediatric AML Patients Below The Age Of 18 Years Who Were Treated With The Same 1ry Treatment Protocol At The National Cancer Institute, Cairo University, During The Period from January 2005 To December 2006. Deaths Were Classified Into Early Deaths (Patients Who Died During 1st Induction Course) And Late Deaths (Patients Who Died Later During Therapy Including Treatment Related Mortality And Deaths Due To Progressive Disease) Results: Early Deaths Were 6/85 (7%), While Late Deaths Were 32/85 Patients (37.6%). The Most Common Cause Of Mortality Among Early Deaths Was Sepsis Which Occurred In 4/6 Patients (66.6%), Followed By Hemorrhage In 1/6 (16.7%), And Hyperleucocytosis In 1/6 (16.7%). On The Other Hand, The Most Common Cause Of Death Among Late Deaths Was Progressive Disease 25/32(78.1%), Followed By Fungal Chest Infection 2/32(6.3%), Septic Shock 2/32(6.3%), Combined Fungal And Septic Shock 1/32 (3.1%), Hypokalemia 1/32 (3.1%) And Hepatitis 1/ 32(3.1%). Fungal Chest Infection Occurred In 47.1% Of The Patients, Of Which 10% Died. Gram -Ve Organism Was The Main Cause Of Sepsis Being Isolated In 50% Of The Septic Episodes where Acitenobacter Was The Most Common Organism Occurring In 30%. Age, TLC And FAB Morphology Had No Significant Effect On Lethal Outcome. Conclusion: Septic Shock Was The Most Common Cause Of Early Deaths, While Progressive Disease, Septic Shock And Fungal Chest Infection Were The Most Common Causes Of Late Deaths Keywords: Pediatrics/ Acute Myeloid Leukemia /Mortality.