الفهرس 
cover EnglishOnly 14 pages are availabe for public view
 |  | from | 190 |  |  |
| | | from | 190 | | |
Abstract
The Low Flow Anesthesia Is A Technique In Which The Fresh Gas Flow Is Significantly Lower Than The Minute Volume (Less Than 1L/Min). This Technique Has Many Advantages Including: • Better Humidification And Warming To The Breathing Gases. • Environmental Benefits Due To Decrease Release Of The Anesthetic Gas To The Environment. • Cost Saving As A Result Of Reducing The Consumption Of The Anesthetic Gas. However, Sevoflurane Is Degraded By CO2 Absorbents (Sodalime And Barium Hydroxide Lime), The Degradation Products Of Which Are Polyfluorinated Haloalkenes, Chiefly Pentafluoro Isopropyl Fluoromethyl Ether (Also Known As Compound A). Compound A Is Nephrotoxic In Dose Dependent Manner In Rats And There Is A Contra Verse On Its Effect On Humans. The Rate At Which CO2 Absorbents Degrade Sevoflurane Is Dependent On The Concentration Of The Anesthetic Gas, The Fresh Gas Flow Rate, The Temperature Of CO2 Absorbent And Types Of CO2 Absorbent. The Aim Of This Work Is To Compare The Effect Of Low Flow Sevoflurane And Isoflurane Anesthesia In Humans, Following Long Duration Surgery, On Renal And Hepatic Functions. It Was Conducted On 60 Adult Patients Scheduled For Surgery Of Suspected Duration ≥ 5 Hours. They Were Divided Into 2 Groups: - ISO-Group - SEVO-Group Each Group Included 30 Patients. A Blood Samples And 24 Hour Urine Samples Were Collected For Each Patient Preoperative And At The 1st, 2nd, 3rd, And 5th Day After Anesthesia. These Samples Were Used For Estimation Of Sensitive Biomarkers For Kidney Function Assessment Includes: - 24 Hour Microprotein In Urine. - 24 Hour Urine Glucose In Urine. - 24 Hour Urine Creatinine In Urine. Regarding BUN And Serum Creatinine, They Didn’t Increase After Low Flow Sevoflurane Anesthesia. There Were Significant Increase In Serum AST, ALT And Bilirubin from Pre-Anesthesia Value With The Peak Increase Occurred At The 3rd Postoperative Day. Serum Alkaline Phosphatase Showed Significant Decrease With The Maximum Decrease At The 3rd Day Postoperative. Serum Lactate Dehydrogenase Showed Non Significant Increase Up To The 5th Day Postoperative. There Were Significant Postoperative Microproteinurea And Glucosuria. There Was Significant Increase In Creatinine Clearance With Peak In The 1st Postoperative Day. In All Previous Investigation, There Were No Statistically Significant Differences Between Isoflurane Group And Sevoflurane Group. In Conclusion, Both Sevoflurane And Isoflurane Have The Same Effect On Liver And Kidney Functions During Low Flow Anesthesia With No Specific Toxicity On The Kidney And Liver Was Observed Due To Sevoflurane Anesthesia.