الفهرس 
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Abstract
The present work was conducted to compare between the possible ameliorating effects of three herbs: hops(H), rosemary(R) and cat’s claw (C C) on hepatic and renal toxicity induced by 7,12-Dimethyl benz(A)antheracene , a hydrocarbon in female rats weighed about 50 g and divided into eight groups.
The obtained result can be summarized as follow:
A single intraperitonial (i.p) dose of DMBA (30mg/Kg b.W) caused the following alterations in comparison with the control group:
1- Significant decrease in the percentage of body weight where is an increase in the hepato somatic index and renal somatic index.
2- The hematological analysis recorded analysis recorded a significant decrease in red blood cells (RBCs), white blood cells (WBCs) and platelets counts . Moreover a decrease in hemoglobin content (Hb), hematocrit ( HCT%),mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) values accompanied by significant increase in mean corpuscular osmatic fragility (MCOF). In addition, the results illustrated an increase in serum total iron binding capacity (TIBC), but decrease in ferritin accompanied with a decrease in iron level in serum and bone marrow but an increase in liver and spleen tissues.
3- Kidney and liver malondialdehyde (MDA) contents and hydrogen peroxide levels (H2O2) were significantly increased and this was accompanied by significant decrease in reduced glutathione (GSH) contents, superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities.
4- The results reported significantly decrease in serum total portein, serum total albumin and globulin and liver total proteins but serum total bilirubin were significantly elevated in the DMBA intoxicated group.
5- Aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and glutamyl-S-transferase (GGT) activities were significantly increased in serum but significantly decreased in the liver.
6- Alkaline phosphatase (ALP) activity was significantly elevated in the serum accompanied with the increase in urea, creatinine concentrations and creatinine clearance in serum and urine. While, ALP activity was significantly decreased in liver and kidney.
On the other hand, intake of hops, rosemary and cat’s claw controlled DMBA toxicity and ameliorated the disturbance observed in most tested parameters and improved liver and kidney functions. In this respect rosemary was the most effective followed by hops and cat’s claw. Accordingly, it can be concluded that intake of hops, rosemary or cat’s claw herbs are effective in reducing DMBA toxicity. Next studies are needed to determine the suitable dose for each herb to perform the most protective efficacy.