الفهرس 
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Abstract
In the present study, the immunizing and protective efficacy of local strains (S. Typhimurium, S. Infantis, S. Enteritidis and S. Meleagridis) and imported ones (S. Typhimurium and S. Enteritidis) in four locally prepared polyvalent and two imported bivalent inactivated vaccines had been studied. A total of 350 six weeks old SPF white lohman layer chickens and 350 two weeks old broiler Ross chickens in different two experiments were divided into 7 groups 50 chicks per each. Group (A) was vaccinated with the alcohol inactivated mineral oil adjuvanted vaccine.Group (B) was vaccinated with the alcohol inactivated gel adjuvanted vaccine. Group (C) was vaccinated with the formalin inactivated mineral oil adjuvanted vaccine.Group (D) was vaccinated with formalin inactivated gel adjuvanted vaccine. Group (E) was vaccinated with the formalin inactivated mineral oil adjuvanted imported vaccine. Group (F) was vaccinated with formalin inactivated gel adjuvanted imported vaccine. Group (G) used as control non vaccinated chicks.
The seven groups were challenged with virulent S. Typhimurium, S. Infantis, S. Enteritidis and S. Meleagridis strains (108 CFU/ml of each) 1ml orally, 3 weeks post boostering of the vaccines. The degree of protection was assessed according to the severity of the clinical signs, the mortality and fecal shedding of the challenged organisms. Blood samples were collected weekly and humoral immune response was measured against Salmonella strains using micro-agglutination test (MAT) and ELISA.
In conclusion, formalin inactivated polyvalent Salmonella vaccines prepared from local field strains (B, C, D and E groups) gives higher protection rates with reduced fecal shedding and higher Salmonella antibody titre than inactivated bivalent Salmonella imported vaccines