الفهرس 
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Abstract
The effect of some food additives (biotin, vitamin C and zinc individually or in-combination) on some biochemical parameters in chickens was investigated.
For performing the present study, 250 clinically healthy, one day old hubbered chicken of both sexes were used. They were classified into 5 main groups. Each group consisted of 50 chicks as follows:
Group I: Chickens were not supplied with any additives to the ration and considered as a control.
Group. II: Chickens were supplied with 0.1 mg biotin/kg ration to the normal ration.
Group III: Chickens were supplied with 40 mg ascorbic acid/kg ration to the normal ration.
Group IV: Chickens were supplied with 50 mg Zinc/kg ration to the normal ration.
Group V: Chickens were supplied with 0.1 mg biotin, 40 mg ascorbic acid and 50 mg Zinc/kg ration to the normal ration.
All food additives were added to ration of chickens after two weeks of chicken age as double fold requirement of each additive. 10 birds from each group were slaughtered for collection of blood samples and also liver and muscles for estimation of glycogen at 4, 6 and 8 weeks of chicken age. All sera were subjected for estimation of the following parameters: total protein, albumin, electrophoresis, glucose, total lipids, triacylglycerol, cholesterol, phospholipids, alkaline phosphatase, creatinine phosphokinase lactate dehydrogenase, calcium, phosphorus,
copper, iron, zinc, T3 and T4.
The obtained results summarized as follows: Protein:
At 4 weeks age of chickens there was significant increase of total protein and total globulin in biotin, vitamin C and zinc. At 6 weeks of age there was significant increase of total protein and total globulin in vitamin C and BCZ groups. At 8 weeks age of chickens there was significant increase of total protein in case of vitamin C, zinc and in-combination groups and increase of albumin in biotin groups and significant increase in total globulin in vitamin C, zinc and BCZ group.
Carbohydrate:
At 4 weeks age there was significant increase of glucose in vitamin C and BCZ groups and significant increase of muscle glycogen in zinc and BCZ group and significant decrease of liver glycogen in biotin and vitamin C groups. At 6 weeks of age there was significant increase of glucose in vitamin C group and decrease in zinc group. In case of muscle glycogen there was decrease in vitamin C group. In case of liver glycogen there was significant increase of BCZ groups. At 8 weeks age of chickens there was significant increase of glucose in biotin, vitamin C and BCZ groups and decrease in zinc group. In case of muscle glycogen there was significant increase in zinc and BCZ group and significant decrease in biotin and vitamin C groups. In case of liver glycogen there was decrease in biotin, vitamin C and BCZ groups.
Lipids:
At 4 weeks age there was a significant decrease of total lipids, cholesterol and triacylglycerol in biotin, vitamin C, zinc and BCZ groups. At 6 weeks of age there was significant decrease of total lipids in biotin group and there was significant decrease of triacylglycerol in biotin, zinc and BCZ groups. There was significant decrease of cholesterol in biotin, vitamin C and BCZ groups also there was a significant decrease of phospholipids in BCZ group. At 8 weeks age of chickens there was significant decrease of triacylglycerol in zinc and BCZ groups also there was a significant decrease of cholesterol in biotin and vitamin C group.
Enzymes:
At 4 weeks age of chickens there was a significant increase of creatine phosphokinase (CPK) in biotin, vitamin C and BCZ group also there was a significant increase of la’tate dehydrogenase (LDH) in biotin group. At 6 weeks of age there was significant increase in CPK and LDH in biotin, vitamin C and BCZ group. At 8 weeks age of chickens there was a significant increase of CPK and LDH in biotin group only. At 4 weeks age there was a significant increase of phosphorus in
biotin, zinc and BCZ groups also there was a significant decrease of iron
in biotin group and a significant increase of zinc in BCZ group. At 6
weeks of age there was a significant increase of phosphorus and copper in
BCZ group also there was a significant increase of iron in vitamin C
group and decrease in biotin group. There was a significant increase of • zinc in zinc and BCZ treated-groups. At 8 weeks age of chickens there
was marked increase of phosphorus in biotin, vitamin C, Zinc and BCZ groups. In case of serum zinc there was marked increase and in zinc and BCZ groups. Also, there was an increase of serum copper in biotin,
vitamin C and BCZ treated-groups. Thyroid hormones:
At 4 weeks age there was a marked increase of T3 and T4 in BCZ groups also at 6 weeks of age of chicken there was a significant increase of T3 and T4 in vitamin C and BCZ groups. The same results appear at 8 weeks of age, where there was significant increase of T3 and T4 in
vitamin C and BCZ groups.