الفهرس 
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Abstract
The current study was conducted to better understand the epidemiology of avian influenza virus (AIV) in the chicken farms in Egypt during 2012-2013. A total of 17 positive H5N1 and 39 positive H9N2 from 200 chicken farms were suffered from problems such as mortality and respiratory signs. Delta had the incidence of AIV H5 and H9 which was 9.4% and 18.8% respectively while the Upper Egypt recorded 7.7% and 20% Moreover the highest incidence of the disease was during the winter while the lowest incidence was during the summer. The intravenous pathogenicity index (IVPI) was conducted to assess the pathogenicity of 3 H5N1 AIV isolates. The IVPI of selected H5 viruses was range from 2.67 to 2.91 and this indicated that the selected H5 viruses were HPAI. And one of them had been used to evaluate Protective efficacy of the current available inactivated H5 vaccines (Re-H5N3, H5N2 and Re-H5N1 vaccines) and vectored AI (HVT-H5) vaccine under lab condition in broiler chickens. There was no vaccine able to afford the required protection against HPAI H5N1 2012 after single vaccination except the vectored AI (HVT-H5) vaccine afforded 93.3% protection.