الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 91 |  |  |
| | | from | 91 | | |
Abstract
Diabetes is known to be one of the most potent risk factors for coronary heart disease and stroke in women and men. It is now accepted that high blood glucose levels prior to or shortly after cerebral infarction have an adverse effect on prognosis. Besides, an increased risk of incident coronary heart disease and stroke was found in people without diabetes, with an elevated HbA1c.
Our study was a correlation study included 90 patients with acute ischemic stroke admitted to the units of the critical care department of Alexandria Main University Hospital. The aim of the study was to establish the role of prolonged hyperglycemia on the short term prognosis of acute ischemic stroke through assessing 2 different variables:
3. Modified Rankin Scale .
4. Development of haemorrhagic transformation.
All patients included in the study were subjected to the following:
5. Demographic data including :
Name, Age, Sex, Marital status and Socioeconomic class .
6. Medical history and risk factors as :
Diabetes,dyslipidemia, cardiac source of embolization, deep venous thrombosis, previous TIA and hypertension
7. Clinical data:
Patient diagnosis : acute ischemic stroke
Data regarding management of the patient including : treatment modalities either thrombolytic therapy or anticoagulation
In- hospital outcome whether recovery , in-hospital mortality , or in-hospital complications such as haemorrhagic transformation,expanding of infarction or disabilities.
Modified Rankin scale was used to assess the patient’s outcome .(table 1)
8. Laboratory investigations
C. In all patients a random admission blood glucose level was measured as soon as they entered the emergency unit and HbA1c (to know if blood sugar controlled or not) was determined within the first 24 hours.(37)
According to these two parameters, patients were categorized into one of three groups :
4. Uncontrolled diabetics group with admission blood glucose > 140 and HbA1c>8%.
5. Controlled diabetics group with admission blood glucose >140 and HbA1c <8 %.
6. Non diabetic group (control group) with admission blood glucose < 140 and HbA1c < 8 %.
Random blood glucose measurements were followed up 4 times a day(every six hours) for 10 days after the stroke and the mean of these measurements were calculated as the mean glycemic regulation (MGR). Blood glucose levels were aimed to be kept below 250 mg/dl by appropriate doses of insulin. Patients received subcutaneous insulin.treatment adjusted to the blood glucose level using standard insulin schedule of hyperglycemia.(47-50)
D.routine blood testing were done for every patient in the study including complete blood picture (CBC),renal function (Urea and Creatinine),serum electrolytes (Na and K),liver functions (SGOT and SGPT)and coagulation profile (INR,PTT and PT).