الفهرس 
Aim of WorkOnly 14 pages are availabe for public view
 |  | from | 171 |  |  |
| | | from | 171 | | |
Abstract
The main goal of this study was to discover bioactive natural products with pharmacological potential by employing various biotechnological methods. Marine fungi have been identified as a promising resource for such molecules. In particular, fungi living in the inner tissue of marine algae (endophytes) were found capable of producing a structurally and with regard to their bioactivity, most intriguing array of compounds. For achieve this purpose, our teamwork consist of many collaborating groups, Marine Biology, Marine Microbiology, Marine natural products chemistry and Pharmacology group.
This study focused on the two marine-derived fungi Emericella nidulans and Penicilliun chrysogenum. Both fungi cultivated in artificial media mimicking the marine environment and investigated for their bioactive secondary metabolites. The investigation dealt with the isolation, identification and biological evaluation of the fungal natural products with emphasis on compounds exhibiting cytotoxic and antimicrobial activities as well as inhibiting HCV protease enzyme.
1. Fungal isolation and culture conditions:
The brown alga Turbinaria elatensis was collected from the Egyptian Red Sea site at a depth of 3-6 m, while red alga Liagora viscid was collected at a depth of 5-8 m from the coast of Rass Mohamed (south Sina, Egypt) in March 2010. The samples were identified by the Coral Reef Ecology and Biology group, National Institute of Oceanography and Fisheries, Suez, Egypt.