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Abstract Psoriasis is a worldwide chronic relapsing autoimmune hyperproliferative skin disease. The most characteristic lesion consists of dusky red, sharply demarcated, scaly plaques which are particularly present over the extensor surfaces and scalp. Psoriasis is variable in duration and extent. It varies in severity from minor localized plaques to complete body coverage. Psoriasis is now considered a chronic inflammatory disease. Comorbidities play a major role in driving the lower quality of life experienced by patients with psoriasis. Fundamentally, they also contribute to the reduction in life expectancy reported in patients with moderate to severe psoriasis. There is strong evidence to suggest that the presence of a complex interplay between psoriasis, genetic factors and obesity drives the high incidence rates of metabolic diseases seen in patients. Evidence also points to the presence of psoriasis being an independent risk factor for cardiovascular diseases, while emerging researches highlight the importance of identifying and monitoring cardiovascular diseases risks in these patients. |