الفهرس 
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Abstract
This study was designed to investigate the hepatoprotective and antioxidant activities of Cynara scolymus leaves extract against N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl4)-induced hepatocellular carcinoma in rats. Rats were pretreated with Cynara scolymus extract, silymarin and their combination for six weeks prior to the injection of NDEA. Then rats received a single injection of NDEA followed by weekly subcutaneous injections of CCl4 for six weeks. The pretreatment were then continued for another six weeks along with the injection of CCl4.The obtained results showed that pretreatment with Cynara scolymus extract, silymarin and their combination limited the toxic effects of NDEA and CCl4. This study concluded that Cynara scolymus extract has a protective effect against experimentally induced hepatocellular carcinoma in rats and the combination of both extracts showed the best effect in preventing the development of hepatocarcinogenesis.