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Abstract Neonatal sepsis continues to be a major cause of morbidity and mortality in neonatal period despite the use of modern antibiotics and resuscitation therapies.(4) Also there are many pathogens associated with neonatal sepsis which vary in different counteries and tend to change over time,(5) so the early diagnosis and determination of the severity of sepsis is very important, because it will increase the possibility of starting early and specific treatment.(6) Diagnosis of neonatal sepsis remains as a major challenge despite advances in medicine. Despite the availability of acute phase proteins as sepsis markers, such as c-reactive protein (CRP), procalcitonin (PCT), tumour necrosis factor and serum amyloid-A, there is no ideal marker that can reliably differentiate infected and non infected neonate.(8) Also the diagnosis of sepsis and evaluation of its severity is complicated by the highly variable and non-specific nature of the signs and symptoms of sepsis.(9) |