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Abstract Carcinoma of the breast is the most prevalent cancer among Egyptian women and constitutes 29% of National Cancer Institute cases, median age at diagnosis is one decade younger than in countries of Europe and North America and most patients are premenopausal; tumors are relatively advanced at presentation (Siegel, et al., 2012). Breast cancer is the leading cause of cancer related mortality in women worldwide, almost half of annually diagnosed women with breast cancer belong to developing countries .These women also have poor overall outcomes compared to women in developed countries. The advanced stage of presentation of breast cancer in developing countries was attributed to a lack of mass education and screening programs, poverty, poor access to health care facilities, lack of expertise, and poor country infrastructure (Kumar, et al.,2011). Our results were similar to other studies from developing countries. The majority of tumors are invasive duct carcinoma. This over view examines prognostic markers and end results of surgery, radiotherapy and systemic therapy for early, locally advanced and metastatic disease stages we described the epidemiological profile of breast cancer in the clinical oncology department Menofia University. The purpose of the present study was to report the pathological features and clinical outcome of all breast cancer cases diagnosed in 5 years from January 2000 till December 2004. Total number of cancer patients represented to our clinical oncology department in 5 years was 3494 and number of breast cancer Summary & Conclusions 138 patients was 1048 patients; so cancer breast constitute about 30% of cancer patients presented to our department. In this study we excluded 76 patients who were diagnosed with breast cancer and not completed their treatment and follow up at our clinical oncology department so; our thesis include 972 patients who diagnosis, treated and were followed up till the end of December 2010. It was found that the mean age was 48.55 years (range 23- 86).Female patients represent (99%) and male patients (1%). (52.3%) were premenapusal and (46.7%) were postmenapusal. Invasive ductal carcinoma was the most common (94.2%). Stage III was the most frequent (46.7%) followed by stage II (39.5%).MRM was the comments type of surgery (91.4%). In early breast cancer the median overall survival was 65 months and median DFS was 55 months .There was statistically significant correlation between overall survival and nodal status, HER-2 status, type of surgery, adjuvant chemotherapy, postoperative radiotherapy, hormonal treatment and site of relapse in univarte and in multivariate analysis. In stage III median overall survival was 42 months and median DFS was26 months. In stage IV median overall survival was 17 months and median progression free survival is 10 months. Markers of poor prognosis for survival were increasing number of positive lymph nodes, stage of disease, and HER-2 status and variable treatment profiles. Clinical outcomes and survival associated for each prognostic marker were inferior when compared to developed Summary & Conclusions 139 countries due to low level of awareness, lack of screening programs, and subsequent late access to treatment due to financial problems and interruption of administration of treatment. from this audit we need to improve population based screening programs, outreach mammography, improvements in technical expertise and quality of care, standardized treatment regimens in our country which has limited resources. |