الفهرس 
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Abstract
The oral LD50 of Basagran in Agoza strain
tQmale rats was found to be (380 mg/kg B,W~)0
The clinical symptoms which appears on
animals during determination of T~D50 and these
administered 350 mg/K.g B.W. at 18 days of gesta—
tion were skin rash on nose, mouth, eyes, swelling
at the maxilla of fore limb on the right side and
tremors all over the body.
Organs from animals died during the
determination were preserved in 10% formaline and
histopatholc’gical examination were carried out.
Examination revealed presence of telangectasis in
liver with coagulative necrosis of the hepatic cell.
Lung showed nedema in the perivascular areas and air
alveoli lymphoid cell hyperplasia were noticed.
cloudy swelling and coagulative necrosis in kidney.
Isohemic neural damage of purkinge cells in brain,
diffuse gliosis in the white matter and perivascular
gliosis were noticed.
Distribution of Basagran in different organs
was determined (in a group received 380 mg.Kg B.W
by combined thin layer chrnniatrgraphic technique and
ultra violet spectrnphotnmeteric analysis.
The effect of Basagran on pregnant mothers,
foeti placenta and embryones were investigated through
intragastric intubaction with 350 mg,ICg.B.W.dose of
Basagran at 18 days of gestation period to 18 animals,
Cesarian sections were carried out en 18 animals after
24 hours pest administration foeti, umbilical cord,
placenta and mother organs were subjected to histo—
pathological examination results showed the same pre
vious his tcpatholc’gical lesion,
The most important colour tests which gave posi
tive results with Basagran were vitalis test (bloody
red colour) Isieberman’s test (yellow lemon colour),
Frohad’s test (violet colour) and mandelin’s (red
colour)
The RF values of Basagran on silica gel using
mixture of some aromatic hydrocarbones were also
determined. The spectrophotometeric analysis showed
that Basagran has an absorption maxima at 270 nm
wavelength.
Thin layer chro’matographic analysis provide the
presence of Basagran in embryonic tissues—extract.
Teratological effect of Basagran were investi—
gajed on sixty pregnant Agoza strain female rats,
classified into 5 groups (each 12 animals) A, B, C,
D, E and each group was classified into four sub
groups each contains 3 animals (A1, A2, A3, A4, B1,
B2, B3 etc). A single oral administ
ration of herbicide was carried out at different
period of gestation (6, 8, 11, 14, 16).
Three doses (25, 90, 200 -mg/Kg B0W.) were used
at each gestation interval.
The teratolr’gical studies showed that:
1. The resorption of freti were high in groups
administered the herbicide at 6, 8 days of
gestation (75%-60%). Then gradually lowered
in groups dosed at 11, 14, 16 days of
gestation.
2. The size of the foeti were smaller than centre].,
Absence of coccygeal vertebra.e was recorded in
all groups, Metacarpal, metatarsal phalanges
were absent in all groups except in group dosed
at 16th days of gestation.